The Siskiyou-Hargadine Historic District remains one of Ashland's earliest and most intact residential neighborhoods.

Bisected by Siskiyou Boulevard, the grand entrance to the town developed in the last years of the 19th century, the area retains high integrity in design and association, reflecting the growth of this portion of the city of Ashland that began in the late 1880s with the arrival of the railroad and that continued though increased infill development in this historic neighborhood in the years following World War II.

Settled in 1852, Ashland developed around the area now known as the Plaza, the town's physical and economic core. By 1880 residents were beginning to construct homes along Main Street extending south from the Plaza and, after 1888 along the city's newly laid out Siskiyou Boulevard and within the several additions platted above and below this thoroughfare.

Adapted from the NRHP nomination submitted in 2002.