The Myron Angel House is significant chiefly for its association with Myron Angel, a noted journalist, historian and educational advocate known as the "Father of California Polytechnic State University." It is secondarily important as a well-preserved example of late 19th century vernacular residential architecture.

Angel was born in Oneonta, New York, in 1827. He was orphaned at age fifteen. He attended the United States Military Academy at West Point.

After arriving in California in 1849, Angel mined for gold in the Feather River and North San Juan Ridge mining districts, then he was a rancher near Chico before he became a journalist. Like many itinerant printers of the era, he edited newspapers in different towns including Placerville and Oakland in California and Austin in Nevada.

In 1883, Angel settled in San Luis Obispo to edit the Weekly Tribune and later the Daily Republic.

He moved into this house in 1889 and lived here until his death in 1911.

Source: Adapted from the NRHP nomination submitted in 1982.