South Oakdale Historic District is a lineal, 32-acre district in which South Oakdale Avenue forms the spine. The district, containing some seventy buildings, is perhaps the grandest of several well-preserved residential neighborhoods in Medford dating from the city's founding with the coming of the Oregon and California Railroad in 1883.

On either side of the tree-lined corridor are stately and more modest homes ranging in date from the late 1890s to the 1940s and including examples of the Queen Anne, Bungalow, Tudor Revival, Colonial Revival and other period styles. Outstanding among the residences are a number designed by the area's preeminent architect of the period, Frank Chamberlain Clark.

Adapted from the NRHP nomination submitted in 1966.

In 1982, a single building, the Amy Fay Gifford House, was added to the district.