Dr. William G. Irwin commissioned the Reid brothers to design his family home on Lafayette Park, high above San Francisco Bay.

After Irwin's death in 1914, the building housed the country's first blood repository, later named the Irwin Memorial Blood Bank in 1941.

The Irwin Mansion was destroyed by fire in the late 1950s, and a twelve-story building, Washington Tower Apartments, replaced it.

You can see the Irwin Mansion in the 1934 movie, Fog Over Frisco, starring Bette Davis.