The Jackson Brewing Company Historic District covers eight acres containing six contributing buildings.

It is historically significant for its association with early commercial brewing in San Francisco, one of the city's major historical industries, and it and exemplifies the socio-economic pattern of local breweries, prior to Prohibition, many of which were family-owned and operated businesses established - or furthered - by recent northern European immigrants.

Romanesque Revival is the dominant architectural style employed in the design of the Jackson Brewing Company district.

The masonry construction of the complex of rectangular forms, expressing weight and mass, is relieved by round-headed arches; all are elements associated with medieval architecture. The medieval imagery is carried out primarily through the use of exposed red brick, and further enhanced by the contrasting color of grey Colusa sandstone used for details, especially as the foundation (two to three rusticated courses to one dressed course) along Folsom and list Streets.

Excerpted from the NRHP nomination dated 14 January 1993.

The Jackson Brewing Company is also San Francisco Landmark 199.