Saint Vincent's Hill Historic District, which contains 542 contributing buildings, is significant in the development of Vallejo. It represents the close connection between families associated with the Saint Vincent Ferrer Catholic Parish and Mare Island Naval Shipyard.

The pattern of buildings shows how the area prospered and changed to reflect workforce changes on Mare Island and the influences of the Irish Catholic people who lived in the District. The architecture ranges from very simple, early vernacular buildings to grand buildings that represent the fashionable styles of the day.