This National City California Southern Railroad depot built in 1882 served as the first Pacific Coast terminus station of the Santa Fe Railway system's transcontinental railroad. The station was the West Coast general office and figured prominently in Santa Fe's effort to break the economic and transportation monopoly of California held by the Central/Southern Pacific Railroads. The first transcontinental trains arrived in November 1885, resulting in one of the largest land booms in the history of California. Of the original five transcontinental railroad terminus stations, this unique Italianate designed station is the lone survivor.

Citation from California Office of Historic Preservation