The Edward G. Manasse House is significant for its association with Edward G. Manasse, one of the city's most important manufacturers during the first half of the 20th century. Manasse was a key participant in the operation and expansion of one of Napa's largest industrial concerns, the Sawyer Tannery.

Manasse had the house built around 1905 after he had become an officer in the company. He lived here until his death in 1944.

The building is virtually unaltered since its construction.

Source: Adapted from the NRHP nomination submitted in 1993.