The National Register Statement of Significance reads:

This, the only Nob Hill mansion to survive the earthquake and fire of 1906, was the residence of one of the bonanza kings of the Nevada Comstock Lode.

James Clair Flood (1825-1889) operated a saloon when he came to San Francisco in 1849, but by shrewd dealing in the stock exchange and the judicious exploration and development of mines - the Comstock Mine in particular - he amassed a tremendous fortune.

For more information about the Flood Mansion, please see San Francisco Landmark 64.