The Yreka Bakery (spelled and pronounced equally correct forward or backward), was founded here in 1856 by alleged Civil War deserter Frederick Deng. The business actually began at another location and then moved across the street before finally settling in this brick building. There were several owners, but the bakery operated continuously until 1965. Early newspapers advertised 12 loaves of bread for a dollar (delivered daily), and a full assortment of other baked goods at reasonable prices. When the bakery vacated, another business moved in with a name that carried on the palindromic tradition: Yrella Gallery.

A one-story business house initially owned by J.P. Smith occupied this site until the fire of 1871. Rebuilt in 1875, the structure witnessed a myriad of business ventures including several general merchandise stores and a Greek restaurant. The second story false front, pressed-metal façade was added by new owners Morrison and Lash in 1896. The most notable business was Con Brown's Billiard Parlor which operated 21 years in this section. During WW II, Conly Brown gave his billiard tables to the Tulelake Japanese Relocation Center.

The damage to this building in the great fire of 1871 was only $100, no doubt a result of its brick construction. Built by Abel Witherill in 1859 (the same year Yreka was illuminated by gas light), an assortment of short-lived businesses operated on this site until the Yreka Journal moved here in 1883. This generally Republican oriented newspaper published at this location until 1915 when the Siskiyou News bought the building. The News moved 26 years later, and Witherill's building became a warehouse for a time before it provided space for several retail businesses including a steak house and fabric store. Today, the strong architecture of this Miner Street front depicts the strength and romance of the era in which the building was built.

I.O.O.F. Yreka Lodge #19 was instituted in 1853 and has been at this location since that date. Multiple transactions in ownership and lot size and shape occurred before two, one-story brick buildings were erected on this site. These buildings provided the foundation for the I.O.O.F.'s second story meeting hall. After the fire of 1871, the entire building was rebuilt using the undamaged brick walls. The vault in McConnell and McManus' ground level store proved a safe place to keep several kegs of powder that escaped the blaze without igniting. The Odd Fellows acquired sole ownership of the entire building in 1897 and rented space to many different establishments through the years, including a drug store business, which commenced in 1935 and operated under various owners until it finally closed in early 1990.