The Drexler-Colombo Building is in the Jackson Square Historic District. It stands at the intersection of Columbus, Montgomery, and Washington Streets facing two other San Francisco landmarks, the Fugazi Bank Building and the Columbus Savings Bank. The Montgomery Block, California Landmark 80, also stood at this intersection, but it was demolished and replaced by the Transamerica Pyramid. The midrise building in the background of the photograph stands on the site of the historic International Hotel, also demolished.